Nuclear-targeted siRNA delivery for long-term gene silencing
نویسندگان
چکیده
منابع مشابه
Nuclear-targeted siRNA delivery for long-term gene silencing† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc04293g Click here for additional data file.
Developing effective nonviral siRNA delivery systems for long-term gene silencing remains a great challenge. Here we present a nuclear-targeted siRNA delivery system that can induce long-term gene silencing in cancer cells. The nanocarrier consists of gold nanoparticles modified with a dense shell of synthetic siRNAs and nuclear localization signal (NLS) peptides. The NLS peptide could transloc...
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2017
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c6sc04293g